Snake α-Neurotoxin Binding Site on the Egyptian Cobra (Naja haje) Nicotinic Acetylcholine Receptor Is Conserved
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چکیده
منابع مشابه
Snake alpha-neurotoxin binding site on the Egyptian cobra (Naja haje) nicotinic acetylcholine receptor Is conserved.
Evolutionary success requires that animal venoms are targeted against phylogenetically conserved molecular structures of fundamental physiological processes. Species producing venoms must be resistant to their action. Venoms of Elapidae snakes (e.g., cobras, kraits) contain alpha-neurotoxins, represented by alpha-bungarotoxin (alpha-BTX) targeted against the nicotinic acetylcholine receptor (nA...
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Snake alpha-neutotoxins of Elapidae venoms are grouped into two structural classes, short-chain and long-chain alpha-neutotoxins. While these two classes share many chemical and biological characteristics, there are also distinct dissimilarities between them, including their binding site on the nicotinic acetylcholine receptor (nAChR), specificity among species of Chordata, and the associated p...
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Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer model...
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A neurotoxin, designated toxin LY, has been isolated from the venom of the Egyptian cobra (Naja haje haje) by gradient chromatography on Amberlite CG-50, and has been further purified by gel filtration on Sephadex G-50. Homogeneity was verified by free boundary electrophoresis, acrylamide gel electrophoresis, sedimentation velocity, amino acid analysis, and end group analysis. Toxin LY has a se...
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BACKGROUND The study of craniofacial development is important in understanding the ontogenetic processes behind morphological diversity. A complete morphological description of the embryonic skull development of the Egyptian cobra, Naja h. haje, is lacking and there has been little comparative discussion of skull development either among elapid snakes or between them and other snakes. METHODO...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2001
ISSN: 1537-1719,0737-4038
DOI: 10.1093/oxfordjournals.molbev.a003967